Drugplain

Nystatin 100000 [USP'U]/g

Nystatin · CREAM · Padagis Israel Pharmaceuticals Ltd

10 Recalls on Record
Plain English

Nystatin cream is a prescription antifungal medication applied directly to the skin to treat fungal infections caused by Candida and other susceptible fungi. It works by disrupting the fungal cell membrane to stop the infection from spreading.

Key Facts

Brand Name
Nystatin
Generic Name
Nystatin
NDC Code (Product)
45802-059
Manufacturer
Padagis Israel Pharmaceuticals Ltd
Strength
100000 [USP'U]/g
Dosage Form
CREAM
Route
TOPICAL
Marketing Status
Application #
ANDA062225
Drug Class
Polyene Antifungal [EPC]
Marketing Start
09/21/2006

Recall History

10 Recalls on Record
Class II12/11/2023

Fagron, Inc

Labeling: Label Error on Declared Strength: Assay value on the label is incorrect.

OngoingVoluntary: Firm initiated
Class II01/14/2020

Pharmaceutical Associates Inc

Subpotent: Out of specification for assay at the 12-month time point.

TerminatedVoluntary: Firm initiated
Class II09/21/2018

Dr. Reddy's Laboratories, Inc.

Failed stability specifications - An out of specification result was observed for the test parameter : composition of Nystatin during stability testing.

TerminatedVoluntary: Firm initiated
Class II05/17/2017

X-Gen Pharmaceuticals Inc.

Presence of Foreign Substance: potential presence of plastic particles.

TerminatedVoluntary: Firm initiated
Class II12/11/2023

Fagron, Inc

Labeling: Label Error on Declared Strength: Assay value on the label is incorrect.

OngoingVoluntary: Firm initiated
Class II06/10/2020

Crown Laboratories

Subpotent Drug: Out of specification for assay at the 9-month interval for Nystatin Cream, USP.

TerminatedVoluntary: Firm initiated
Class II03/28/2017

Taro Pharmaceuticals U.S.A., Inc.

Failed Content Uniformity Specifications; out-of-specification (OOS) results 18-month stability

TerminatedVoluntary: Firm initiated
Class II08/04/2020

PAI Holdings, LLC. dba Pharmaceutical Associates Inc

Subpotent drug: Out of specification for assay at the 15-month test interval.

TerminatedVoluntary: Firm initiated
Class III05/17/2017

VistaPharm, Inc.

Failed Impurities/Degradation Specifications: Presence of an impurity peak that exceeds approved specification.

TerminatedVoluntary: Firm initiated
Class III05/29/2018

Pharmaceutical Associates Inc

Resuspension problems: Out of specification for appearance and resuspendability.

TerminatedVoluntary: Firm initiated

Side Effects Reported to FDA

FDA FAERS database · These are reported events, not confirmed side effects

nausea1,947 reports
diarrhoea1,744 reports
fatigue1,743 reports
pneumonia1,604 reports
dyspnoea1,451 reports
off label use1,400 reports
vomiting1,345 reports
drug ineffective1,239 reports
pain1,210 reports
death1,122 reports

Full Prescribing Information

Source: FDA Drug Label (SPL)For healthcare professionals

Indications & Usage

INDICATIONS AND USAGE Nystatin Oral Suspension is indicated for the treatment of candidiasis in the oral cavity.

Dosage & Administration

DOSAGE AND ADMINISTRATION INFANTS 2 mL (200,000 units) four times daily (in infants and young children, use dropper to place one-half of dose in each side of mouth and avoid feeding for 5 to 10 minutes). NOTE: Limited clinical studies in premature and low birth weight infants indicate that 1 mL four times daily is effective. CHILDREN AND ADULTS 4 to 6 mL (400,000 to 600,000 units) four times daily (one-half of dose in each side of mouth). The preparation should be retained in the mouth as long as possible before swallowing. Continue treatment for at least 48 hours after perioral symptoms have disappeared and cultures demonstrate eradication of Candida albicans .

Contraindications

CONTRAINDICATIONS The preparation is contraindicated in patients with a history of hypersensitivity to any of its components.

Adverse Reactions

ADVERSE REACTIONS Nystatin is well tolerated even with prolonged therapy. Oral irritation and sensitization have been reported. (See PRECAUTIONS: General ). Gastrointestinal: Diarrhea (including one case of bloody diarrhea), nausea, vomiting, gastrointestinal upset/disturbances. Dermatologic: Rash, including urticaria has been reported rarely. Stevens-Johnson syndrome has been reported very rarely. Other: Tachycardia, bronchospasm, facial swelling, and non-specific myalgia have also been rarely reported.

Frequently Asked Questions

What is Nystatin used for?

Nystatin cream is a prescription antifungal medication applied directly to the skin to treat fungal infections caused by Candida and other susceptible fungi. It works by disrupting the fungal cell membrane to stop the infection from spreading.

Is Nystatin a controlled substance?

Nystatin is not classified as a controlled substance by the DEA.

What is the generic name for Nystatin?

The generic name for Nystatin is Nystatin. There are 9 other brand versions of Nystatin.

What is the NDC code for Nystatin 100000 [USP'U]/g?

The NDC (National Drug Code) for Nystatin 100000 [USP'U]/g is 45802-059, listed by Padagis Israel Pharmaceuticals Ltd.