Drugplain

Methocarbamol 100 mg/mL

Methocarbamol · INJECTION, SOLUTION · Fresenius Kabi USA, LLC

10 Recalls on Record
Plain English

Methocarbamol is a injection, solution containing methocarbamol at 100 mg/mL, taken intramuscular. Manufactured by Fresenius Kabi USA, LLC.

Key Facts

Brand Name
Methocarbamol
Generic Name
Methocarbamol
NDC Code (Product)
63323-778
Manufacturer
Fresenius Kabi USA, LLC
Strength
100 mg/mL
Dosage Form
INJECTION, SOLUTION
Route
INTRAMUSCULAR, INTRAVENOUS
Marketing Status
Application #
ANDA209331
Drug Class
Muscle Relaxant [EPC]
Marketing Start
04/17/2018

Recall History

10 Recalls on Record
Class II01/02/2019

Hiers Enterprises, LLC dba Northwest Compounding Pharmacy

Lack of sterility assurance.

TerminatedVoluntary: Firm initiated
Class II03/15/2021

Cardinal Health Inc.

CGMP Deviations: Intermittent exposure to temperature excursion during storage.

TerminatedVoluntary: Firm initiated
Class I09/17/2018

Endo Pharmaceuticals, Inc.

Labeling: Incorrect Instructions: Dosage information on the immediate container label incorrectly states "Two to four tablets four times daily." rather than the correct dosage of "Two tablets three times daily."

TerminatedVoluntary: Firm initiated
Class II10/19/2013

Specialty Medicine Compounding Pharmacy

Lack of Assurance of Sterility: All unexpired sterile compounded human and veterinary products are being recalled because they were compounded in the same environment and under the same practices as another product found to be non-sterile and therefore sterility cannot be assured.

TerminatedVoluntary: Firm initiated
Class II03/21/2025

Somerset Therapeutics Private Limited

Lack of Assurance of Sterility: Media fill with bacterial contamination

OngoingVoluntary: Firm initiated
Class II11/14/2014

Attix Pharmaceuticals

Penicillin Cross Contamination: All lots of all products repackaged and distributed between 01/05/12 and 02/12/15 are being recalled because they were repackaged in a facility with penicillin products without adequate separation which could introduce the potential for cross contamination with penicillin.

TerminatedVoluntary: Firm initiated
Class III08/11/2015

Golden State Medical Supply Inc.

Presence of Foreign Substance: Presence of hair.

TerminatedVoluntary: Firm initiated
Class II05/26/2017

American Pharmaceutical Ingredients LLC

CGMP Deviations: Lack of quality assurance at the API manufacturer.

TerminatedVoluntary: Firm initiated
Class II07/02/2013

Aidapak Services, LLC

Labeling: Label Mixup: METHOCARBAMOL, Tablet, 500 mg may have potentially been mislabeled as the following drug: LOSARTAN POTASSIUM, Tablet, 25 mg, NDC 00093736498, Pedigree: AD46312_16, EXP: 5/16/2014.

TerminatedVoluntary: Firm initiated
Class I02/15/2024

Eugia US LLC

Presence of Particulate Matter

OngoingVoluntary: Firm initiated

Side Effects Reported to FDA

FDA FAERS database · These are reported events, not confirmed side effects

fatigue1,168 reports
pain1,165 reports
nausea1,107 reports
drug ineffective1,068 reports
headache883 reports
diarrhoea789 reports
fall774 reports
off label use738 reports
dyspnoea732 reports
arthralgia701 reports

Full Prescribing Information

Source: FDA Drug Label (SPL)For healthcare professionals

Indications & Usage

INDICATIONS AND USAGE Methocarbamol tablets, USP are indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of methocarbamol has not been clearly identified, but may be related to its sedative properties. Methocarbamol does not directly relax tense skeletal muscles in man.

Dosage & Administration

DOSAGE AND ADMINISTRATION Methocarbamol tablets, USP, 500 mg – Adults: Initial dosage: 3 tablets q.i.d. Maintenance dosage: 2 tablets q.i.d. Methocarbamol tablets, USP: 750 mg – Adults: Initial dosage: 2 tablets q.i.d. Maintenance dosage: 1 tablet q.4h. or 2 tablets t.i.d. Six grams a day are recommended for the first 48 to 72 hours of treatment. (For severe conditions 8 grams a day may be administered). Thereafter, the dosage can usually be reduced to approximately 4 grams a day.

Warnings

WARNINGS Since methocarbamol may possess a general CNS depressant effect, patients receiving Methocarbamol tablets, USP should be cautioned about combined effects with alcohol and other CNS depressants. Safe use of Methocarbamol tablets, USP has not been established with regard to possible adverse effects upon fetal development. There have been reports of fetal and congenital abnormalities following in utero exposure to methocarbamol. Therefore, Methocarbamol tablets, USP should not be used in women who are or may become pregnant and particularly during early pregnancy unless in the judgment of the physician the potential benefits outweigh the possible hazards (see Precautions, Pregnancy ). Use In Activities Requiring Mental Alertness Methocarbamol may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle. Patients should be cautioned about operating machinery, including automobiles, until they are reasonably certain that methocarbamol therapy does not adversely affect their ability to engage in such activities.

Contraindications

CONTRAINDICATIONS Methocarbamol tablets, USP are contraindicated in patients hypersensitive to methocarbamol or to any of the tablet components.

Drug Interactions

Drug interactions See Warnings and Precautions for interaction with CNS drugs and alcohol. Methocarbamol may inhibit the effect of pyridostigmine bromide. Therefore, methocarbamol should be used with caution in patients with myasthenia gravis receiving anticholinesterase agents.

Adverse Reactions

ADVERSE REACTIONS Adverse reactions reported coincident with the administration of methocarbamol include: Body as a whole: Anaphylactic reaction, angioneurotic edema, fever, headache Cardiovascular system: Bradycardia, flushing, hypotension, syncope, thrombophlebitis Digestive system: Dyspepsia, jaundice (including cholestatic jaundice), nausea and vomiting Hemic and lymphatic system: Leukopenia Immune system: Hypersensitivity reactions Nervous system: Amnesia, confusion, diplopia, dizziness or lightheadedness, drowsiness, insomnia, mild muscular incoordination, nystagmus, sedation, seizures (including grand mal), vertigo Skin and special senses: Blurred vision, conjunctivitis, nasal congestion, metallic taste, pruritus, rash, urticaria

Frequently Asked Questions

What is Methocarbamol used for?

Methocarbamol contains Methocarbamol. It is a injection, solution taken intramuscular. Consult your doctor for specific uses.

Is Methocarbamol a controlled substance?

Methocarbamol is not classified as a controlled substance by the DEA.

What is the generic name for Methocarbamol?

The generic name for Methocarbamol is Methocarbamol. There are 2 other brand versions of Methocarbamol.

What is the NDC code for Methocarbamol 100 mg/mL?

The NDC (National Drug Code) for Methocarbamol 100 mg/mL is 63323-778, listed by Fresenius Kabi USA, LLC.