Lentocilin 1200000 U/4mL
Penicillin G Benzathin · INJECTION, POWDER, FOR SUSPENSION · LABORATRIOS ATRAL, S.A.
Lentocilin is a injection, powder, for suspension containing penicillin g benzathin at 1200000 U/4mL, taken intramuscular. Manufactured by LABORATRIOS ATRAL, S.A..
Key Facts
- Brand Name
- Lentocilin
- Generic Name
- Penicillin G Benzathin
- NDC Code (Product)
84383-110- Manufacturer
- LABORATRIOS ATRAL, S.A.
- Strength
- 1200000 U/4mL
- Dosage Form
- INJECTION, POWDER, FOR SUSPENSION
- Route
- INTRAMUSCULAR
- Marketing Status
- Marketing Start
- 06/01/2024
Recall History
No Recall HistorySide Effects Reported to FDA
FDA FAERS database · These are reported events, not confirmed side effects
Full Prescribing Information
Indications & Usage
Lentocilin S is indicated for the treatment of the following infections in adults and children: - Upper respiratory tract infections, namely group A streptococcal infections - Primary and secondary syphilis - Latent syphilis - Tertiary syphilis (in adults) - Congenital syphilis (in children) - Yaws - Bejel - Pinta Lentocilin S is also indicated prophylactically in the following situations: - Rheumatic fever - Diphtheria (including elimination of the asymptomatic carrier state) Consideration should be given to official guidelines for appropriate use of antimicrobial agents. indications&usage section
Dosage & Administration
Lentocilin S suspension for injection is to be EXCLUSIVELY administered by DEEP INTRAMUSCULAR (IM) INJECTION. Deep IM administration of this medicine requires a rigorous technique and should be performed only by experienced health technicians and in places prepared for the emergency treatment of a possible anaphylactic reaction. Posology Adults Group A streptococcal infections - Upper respiratory tract infections: 1,200,000 IUunits in a single dose. Primary, secondary and early latent syphilis: 2,400,000 unitsIU in a single dose (injection at two different sites). Late latent syphilis or of unknown duration: 2,400,000 unitsIU (injection at two different sites) weekly for 3 consecutive weeks. Tertiary syphilis: 2,400,000 unitsIU (injection at two different sites) weekly for 3 consecutive weeks. Yaws, bejel and pinta: 1,200,000 unitsIU in a single dose. Prophylaxis of rheumatic fever: 1,200,000 unitsIU every 4 weeks. In high-risk patients it is recommended administration of 3 inevery 3 weeks. Prevention of diphtheria, including elimination of the asymptomatic carrier state: 1,200,000 unitsIU in a single dose. Newborns aged ≥ 1 month Asymptomatic congenital syphilis: 50,000 unitsIU/kg…
Contraindications
Hypersensitivity to the active substance, to other penicillin or to any of the excipients. Hypersensitivity to lidocaine or local anesthetics of the amide type.
Drug Interactions
Bacteriostatic antibiotics: Bacteriostatic antibiotics, such as tetracycline, erythromycin and chloramphenicol, may antagonize the bactericidal effect of benzylpenicillin by interfering with active bacterial growth necessary to benzylpenicillin’s effect. Oral contraceptives: The efficacy of oral contraceptives may be impaired in case of concomitant therapy with benzylpenicillin, which may result in an unwanted pregnancy. Women taking oral contraceptives should be alerted to this situation and should be informed about the need to adopt alternative methods of contraception. Methotrexate: Penicillins may reduce the renal excretion of methotrexate causing a potential increase in its toxicity. Probenecid: Probenecid decreases the renal tubular secretion of benzylpenicillin. Its concomitant use with benzylpenicillin can prolong blood levels of benzylpenicillin. Probenecid may be used therapeutically for this purpose.
Adverse Reactions
The most common undesirable effects of benzylpenicillin are hypersensitivity reactions, especially skin rashes. Anaphylactic reactions occurred occasionally, which have sometimes been fatal. The overall incidence of allergic reactions to penicillin ranges between 1 and 10%. Anaphylactic reactions occur in approximately 0.05% of patients, usually after parenteral administration. The following undesirable effects were observed with benzylpenicillin: Blood and lymphatic system disorders - Eosinophilia and hemolytic anemia (both with immunological basis), leukopenia and thrombocytopenia. These effects are usually reversible after discontinuation of treatment. Immune system disorders - Hypersensitivity reactions to penicillin cause a wide variety of clinical syndromes. Immediate reactions include anaphylaxis, laryngeal edema, angioedema, urticaria and maculopapular rashes. Late reactions include hemolytic anemia and immune complex self-limited sickness-like reactions, characterized by fever, malaise, urticaria, arthralgia, myalgia, lymphadenopathy and splenomegaly. In order to determine which patients will probably develop severe allergic reactions, hypersensitivity skin tests may be us…
Frequently Asked Questions
What is Lentocilin used for?
Lentocilin contains Penicillin G Benzathin. It is a injection, powder, for suspension taken intramuscular. Consult your doctor for specific uses.
Is Lentocilin a controlled substance?
Lentocilin is not classified as a controlled substance by the DEA.
What is the generic name for Lentocilin?
The generic name for Lentocilin is Penicillin G Benzathin. There are 7 other brand versions of Penicillin G Benzathin.
What is the NDC code for Lentocilin 1200000 U/4mL?
The NDC (National Drug Code) for Lentocilin 1200000 U/4mL is 84383-110, listed by LABORATRIOS ATRAL, S.A..