Drugplain

ISOVUE 370 755 mg/mL

IOPAMIDOL · INJECTION, SOLUTION · BRACCO DIAGNOSTICS INC

1 Recall on Record
Plain English

ISOVUE 370 is a injection, solution containing iopamidol at 755 mg/mL, taken intravascular. Manufactured by BRACCO DIAGNOSTICS INC.

Key Facts

Brand Name
ISOVUE 370
Generic Name
IOPAMIDOL
NDC Code (Product)
0270-1316
Manufacturer
BRACCO DIAGNOSTICS INC
Strength
755 mg/mL
Dosage Form
INJECTION, SOLUTION
Route
INTRAVASCULAR
Marketing Status
Application #
NDA018735
Drug Class
Radiographic Contrast Agent [EPC]
Marketing Start
12/31/1985

Recall History

1 Recall on Record
Class I11/21/2012

Bracco Diagnostic Inc

Presence of Particulate Matter; fibers identified as cellulose and polyvinyl

TerminatedVoluntary: Firm initiated

Side Effects Reported to FDA

FDA FAERS database · These are reported events, not confirmed side effects

anaphylactic reaction182 reports
urticaria179 reports
dyspnoea176 reports
nausea156 reports
pruritus150 reports
contrast media reaction139 reports
no adverse event135 reports
vomiting120 reports
acute kidney injury111 reports
hypersensitivity103 reports

Full Prescribing Information

Source: FDA Drug Label (SPL)For healthcare professionals

Indications & Usage

1 INDICATIONS AND USAGE ISOVUE is a radiographic contrast agent indicated for: Intra-arterial Procedures † ( 1.1 ) Cerebral arteriography in adults Peripheral arteriography in adults Selective visceral arteriography and aortography in adults Coronary arteriography and cardiac ventriculography in adults Angiocardiography in pediatric patients Intravenous Procedures † ( 1.2 ) Excretory urography in adults and pediatric patients Computed tomography (CT) of head and body in adults and pediatric patients Peripheral venography in adults † Specific concentrations are recommended for each type of imaging procedure. ( 2.2 , 2.3 , 2.4 ) 1.1 Intra-arterial Procedures † ISOVUE is indicated for: Cerebral arteriography in adults Peripheral arteriography in adults Selective visceral arteriography and aortography in adults Coronary arteriography and cardiac ventriculography in adults Angiocardiography in pediatric patients 1.2 Intravenous Procedures † ISOVUE is indicated for: Excretory urography in adults and pediatric patients Computerized tomography (CT) of the head and body in adults and pediatric patients Peripheral venography in adults † Specific concentrations of ISOVUE are recommended for e

Dosage & Administration

2 DOSAGE AND ADMINISTRATION Individualize the volume and concentration according to the specific dosing tables accounting for factors such as age, body weight, size of the vessel, and the rate of blood flow within the vessel. ( 2.2 , 2.3 , 2.4 ) See full prescribing information for important dosage and administration information and directions for use of imaging bulk packages. ( 2.1 , 2.5 ) 2.1 Important Dosing and Administration Information ISOVUE Imaging Bulk Package (IBP) is for intra-arterial or intravenous use only. Do not administer intrathecally [see Warnings and Precautions ( 5.1 )] . Specific concentrations of ISOVUE are recommended for each type of imaging procedure [see Dosage and Administration ( 2.2 , 2.3 , 2.4 )]. Individualize the volume, concentration, and rate of administration of ISOVUE according to the specific dosing tables [see Dosage and Administration ( 2.2 , 2.3 , 2.4 )] . Consider factors such as: age, body weight, blood vessel size and blood flow rate, anticipated pathology and degree and extent of opacification required, structures or area to be examined, concomitant medical conditions, imaging equipment, and technique to be employed. Hydrate patients bef

Contraindications

4 CONTRAINDICATIONS None. None ( 4 )

Adverse Reactions

6 ADVERSE REACTIONS The following adverse reactions are described in greater detail in elsewhere in the labeling: Risks Associated with Intrathecal Administration [see Warnings and Precautions ( 5.1 )] Hypersensitivity Reactions [see Warnings and Precautions ( 5.2 )] Acute Kidney Injury [see Warnings and Precautions ( 5.3 )] Cardiovascular Adverse Reactions [see Warnings and Precautions ( 5.4 )] Thromboembolic Events [see Warnings and Precautions ( 5.5 )] Extravasation and Injection Site Reactions [see Warnings and Precautions ( 5.6 )] Thyroid Dysfunction in Pediatric Patients 0 to 3 Years of Age [see Warnings and Precautions ( 5.8 )] Severe Cutaneous Adverse Reactions [see Warnings and Precautions ( 5.11 )] Most common adverse reactions (incidence >1%) from intra-arterial or intravenous use are pain, hot flashes, burning sensation, nausea, and warmth. ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS, contact Bracco Diagnostics Inc. at 1-800-257-5181 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch . 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly c

Frequently Asked Questions

What is ISOVUE 370 used for?

ISOVUE 370 contains IOPAMIDOL. It is a injection, solution taken intravascular. Consult your doctor for specific uses.

Is ISOVUE 370 a controlled substance?

ISOVUE 370 is not classified as a controlled substance by the DEA.

What is the generic name for ISOVUE 370?

The generic name for ISOVUE 370 is IOPAMIDOL. There are 11 other brand versions of IOPAMIDOL.

What is the NDC code for ISOVUE 370 755 mg/mL?

The NDC (National Drug Code) for ISOVUE 370 755 mg/mL is 0270-1316, listed by BRACCO DIAGNOSTICS INC.