Drugplain

ERYTHROMYCIN 250 mg/1

ERYTHROMYCIN · TABLET, FILM COATED · Nivagen Pharmaceuticals, Inc.

10 Recalls on Record
Plain English

ERYTHROMYCIN is a tablet, film coated containing erythromycin at 250 mg/1, taken oral. Manufactured by Nivagen Pharmaceuticals, Inc..

Key Facts

Brand Name
ERYTHROMYCIN
Generic Name
ERYTHROMYCIN
NDC Code (Product)
75834-242
Manufacturer
Nivagen Pharmaceuticals, Inc.
Strength
250 mg/1
Dosage Form
TABLET, FILM COATED
Route
ORAL
Marketing Status
Application #
ANDA213628
Drug Class
Macrolide [EPC]; Macrolide Antimicrobial [EPC]
Marketing Start
07/15/2021

Recall History

10 Recalls on Record
Class II03/15/2021

Cardinal Health Inc.

CGMP Deviations: Intermittent exposure to temperature excursion during storage.

TerminatedVoluntary: Firm initiated
Class III06/22/2021

Teligent Pharma, Inc.

Failed Impurities/Degradation Specifications

TerminatedVoluntary: Firm initiated
Class II01/28/2015

Akorn, Inc.

Microbial Contamination of Non-Sterile Products: Active Pharmaceutical Ingredient (API) failed USP microbial tests.

TerminatedVoluntary: Firm initiated
Class II04/21/2022

McKesson Corporation dba McKesson Drug Company

CGMP Deviations: all products within expiry are being recalled because the manufacturing firm, Teligent Pharma, Inc.is discontinuing its stability study program.

OngoingVoluntary: Firm initiated
Class II04/29/2026

Zydus Pharmaceuticals (USA) Inc

CGMP Deviations; presence of N-Nitroso-Desmethyl-Erythromycin above the recommended acceptable intake limit

OngoingVoluntary: Firm initiated
Class II10/13/2022

Akorn, Inc.

CGMP Deviations:

OngoingVoluntary: Firm initiated
Class II04/29/2026

Zydus Pharmaceuticals (USA) Inc

CGMP Deviations; presence of N-Nitroso-Desmethyl-Erythromycin above the recommended acceptable intake limit

OngoingVoluntary: Firm initiated
Class III06/07/2012

Fougera Pharmaceuticals, Inc.

Chemical Contamination: This product is being recalled because trace amounts of a plasticizer (Di-Octyl Phthalate) may be present in the product.

TerminatedVoluntary: Firm initiated
Class III06/22/2021

Teligent Pharma, Inc.

Failed Impurities/Degradation Specifications

TerminatedVoluntary: Firm initiated
Class II02/07/2022

Teligent Pharma, Inc.

Failed Impurities/Degradation Specifications: Lot not meeting specification for Unknown Max Related Compounds.

TerminatedVoluntary: Firm initiated

Side Effects Reported to FDA

FDA FAERS database · These are reported events, not confirmed side effects

drug hypersensitivity4,094 reports
nausea1,283 reports
vomiting1,129 reports
drug ineffective1,078 reports
diarrhoea1,077 reports
dyspnoea1,034 reports
fatigue1,030 reports
rash1,017 reports
off label use929 reports
headache867 reports

Full Prescribing Information

Source: FDA Drug Label (SPL)For healthcare professionals

Indications & Usage

INDICATIONS AND USAGE Erythromycin Topical Solution USP, 2% is indicated for the topical treatment of acne vulgaris.

Dosage & Administration

DOSAGE AND ADMINISTRATION Erythromycin Topical Solution USP, 2% should be applied over the affected areas twice a day (morning and evening) after the skin is thoroughly washed with warm water and soap and patted dry. Acne lesions on the face, neck, shoulders, chest, and back may be treated in this manner. This medication should be applied with applicator top. If fingertips are used, wash hands after application. Drying and peeling may be controlled by reducing the frequency of applications.

Warnings

WARNINGS Pseudomembranous colitis has been reported with nearly all antibacterial agents, including erythromycin, and may range in severity from mild to life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents. Treatment with antibacterial agents alters the normal flora of the colon and may permit overgrowth of clostridia. Studies indicate that a toxin produced by Clostridium difficile is one primary cause of “antibiotic-associated colitis”. After the diagnosis of pseudomembranous colitis has been established, therapeutic measures should be initiated. Mild cases of pseudomembranous colitis usually respond to drug discontinuation alone. In moderate to severe cases, consideration should be given to management with fluids and electrolytes, protein supplementation and treatment with an antibacterial drug clinically effective against C. difficile colitis.

Contraindications

CONTRAINDICATIONS Erythromycin Topical Solution USP, 2% is contraindicated in those individuals who have shown hypersensitivity to any of its components.

Adverse Reactions

ADVERSE REACTIONS The following local adverse reactions have been reported occasionally: peeling, dryness, itching, erythema, and oiliness. Irritation of the eyes and tenderness of the skin have also been reported with topical use of erythromycin. Generalized urticarial reactions possibly related to the use of erythromycin, which required systemic steroid therapy have been reported.

Frequently Asked Questions

What is ERYTHROMYCIN used for?

ERYTHROMYCIN contains ERYTHROMYCIN. It is a tablet, film coated taken oral. Consult your doctor for specific uses.

Is ERYTHROMYCIN a controlled substance?

ERYTHROMYCIN is not classified as a controlled substance by the DEA.

What is the generic name for ERYTHROMYCIN?

The generic name for ERYTHROMYCIN is ERYTHROMYCIN. There are 11 other brand versions of ERYTHROMYCIN.

What is the NDC code for ERYTHROMYCIN 250 mg/1?

The NDC (National Drug Code) for ERYTHROMYCIN 250 mg/1 is 75834-242, listed by Nivagen Pharmaceuticals, Inc..