Drugplain

Cromolyn Sodium 40 mg/mL

Cromolyn Sodium · SOLUTION/ DROPS · Sandoz Inc

5 Recalls on RecordCurrently in Shortage
Plain English

Cromolyn Sodium is a solution/ drops containing cromolyn sodium at 40 mg/mL, taken ophthalmic. Manufactured by Sandoz Inc.

Key Facts

Brand Name
Cromolyn Sodium
Generic Name
Cromolyn Sodium
NDC Code (Product)
61314-237
Manufacturer
Sandoz Inc
Strength
40 mg/mL
Dosage Form
SOLUTION/ DROPS
Route
OPHTHALMIC
Marketing Status
Application #
ANDA075282
Marketing Start
06/29/1999

Recall History

5 Recalls on Record
Class II07/21/2023

The Ritedose Corporation

CGMP deviation: product released prior to supplier approval.

CompletedVoluntary: Firm initiated
Class II04/26/2023

Akorn, Inc.

CGMP Deviations: Firm went out of business and could no longer continue stability studies.

OngoingVoluntary: Firm initiated
Class II06/06/2017

Bausch & Lomb, Inc.

CGMP Deviations: Possibility of the presence of microbial contamination in the water used to manufacture this product lot.

TerminatedVoluntary: Firm initiated
Class II08/27/2014

Martin Avenue Pharmacy, Inc.

Lack of Assurance of Sterility: Martin Avenue Pharmacy, Inc. is conducting a voluntary recall of all compounded sterile preparations within expiry. The recall is being initiated in connection with a recent FDA inspection due to observations associated with certain quality control procedures that present a risk to sterility assurance.

TerminatedVoluntary: Firm initiated
Class II10/13/2022

Akorn, Inc.

CGMP Deviations:

OngoingVoluntary: Firm initiated

Side Effects Reported to FDA

FDA FAERS database · These are reported events, not confirmed side effects

treatment failure1,004 reports
drug ineffective276 reports
fatigue165 reports
nausea152 reports
headache140 reports
urticaria129 reports
diarrhoea125 reports
off label use123 reports
hypersensitivity103 reports
malaise103 reports

Full Prescribing Information

Source: FDA Drug Label (SPL)For healthcare professionals

Indications & Usage

Indications and Usage Cromolyn sodium inhalation solution USP is a prophylactic agent indicated in the management of patients with bronchial asthma. In patients whose symptoms are sufficiently frequent to require a continuous program of medication, cromolyn sodium inhalation solution USP is given by inhalation on a regular daily basis (see DOSAGE AND ADMINISTRATION ). The effect of cromolyn sodium is usually evident after several weeks of treatment, although some patients show an almost immediate response. In patients who develop acute bronchoconstriction in response to exposure to exercise, toluene diisocyanate, environmental pollutants, etc., cromolyn sodium should be given shortly before exposure to the precipitating factor (see DOSAGE AND ADMINISTRATION ).

Dosage & Administration

Dosage and Administration For management of bronchial asthma in adults and pediatric patients (two years of age and over), the usual starting dosage is the contents of one vial administered by nebulization four times a day at regular intervals. Drug stability and safety of cromolyn sodium inhalation solution when mixed with other drugs in a nebulizer have not been established. Patients with chronic asthma should be advised that the effect of cromolyn sodium inhalation solution therapy is dependent upon its administration at regular intervals, as directed. Cromolyn sodium inhalation solution should be introduced into the patient's therapeutic regimen when the acute episode has been controlled, the airway has been cleared and the patient is able to inhale adequately. For the prevention of acute bronchospasm which follows exercise or exposure to cold dry air, environmental agents (e.g., animal danders, toluene diisocyanate, pollutants), etc., the usual dose is the contents of one vial administered by nebulization shortly before exposure to the precipitating factor. It should be emphasized to the patient that the drug is poorly absorbed when swallowed and is not effective by this route

Warnings

Warnings Cromolyn sodium inhalation solution has no role in the treatment of status asthmaticus. Anaphylactic reactions with cromolyn sodium administration have been reported rarely.

Contraindications

Contraindications Cromolyn sodium inhalation solution is contraindicated in those patients who have shown hypersensitivity to cromolyn sodium.

Adverse Reactions

Adverse Reactions Clinical experience with the use of cromolyn sodium suggests that adverse reactions are rare events. The following adverse reactions have been associated with cromolyn sodium: cough, nasal congestion, nausea, sneezing, and wheezing. Other reactions have been reported in clinical trials; however, a causal relationship could not be established: drowsiness, nasal itching, nose bleed, nose burning, serum sickness, and stomachache. In addition, adverse reactions have been reported with cromolyn sodium for inhalation capsules. The most common side effects are associated with inhalation of the powder and include transient cough (1 in 5 patients) and mild wheezing (1 in 25 patients). These effects rarely require treatment or discontinuation of the drug. Information on the incidence of adverse reactions to cromolyn sodium for inhalation capsules has been derived from U.S. postmarketing surveillance experience. The following adverse reactions attributed to cromolyn sodium, based upon recurrence following readministration, have been reported in less than 1 in 10,000 patients: laryngeal edema, swollen parotid gland, angioedema, bronchospasm, joint swelling and pain, dizziness

Frequently Asked Questions

What is Cromolyn Sodium used for?

Cromolyn Sodium contains Cromolyn Sodium. It is a solution/ drops taken ophthalmic. Consult your doctor for specific uses.

Is Cromolyn Sodium a controlled substance?

Cromolyn Sodium is not classified as a controlled substance by the DEA.

What is the generic name for Cromolyn Sodium?

The generic name for Cromolyn Sodium is Cromolyn Sodium. There are 6 other brand versions of Cromolyn Sodium.

What is the NDC code for Cromolyn Sodium 40 mg/mL?

The NDC (National Drug Code) for Cromolyn Sodium 40 mg/mL is 61314-237, listed by Sandoz Inc.