Drugplain

Adapalene 1 mg/g

Adapalene · GEL · Walgreens

4 Recalls on Record
Plain English

Adapalene is a retinoid gel applied to the skin to treat acne. It is available over-the-counter and works by helping to unclog pores and reduce acne breakouts.

Key Facts

Brand Name
Adapalene
Generic Name
Adapalene
NDC Code (Product)
0363-4110
Manufacturer
Walgreens
Strength
1 mg/g
Dosage Form
GEL
Route
TOPICAL
Marketing Status
Application #
ANDA090962
Drug Class
Retinoid [EPC]
Marketing Start
07/01/2025

Recall History

4 Recalls on Record
Class II02/12/2024

MCKESSON CORPORATION

CGMP Deviations: Product was stored outside labeled storage temperature requirements. Product was exposed to controlled room temperature environment instead of remaining refrigerated.

TerminatedVoluntary: Firm initiated
Class II11/14/2014

Attix Pharmaceuticals

Penicillin Cross Contamination: All lots of all products repackaged and distributed between 01/05/12 and 02/12/15 are being recalled because they were repackaged in a facility with penicillin products without adequate separation which could introduce the potential for cross contamination with penicillin.

TerminatedVoluntary: Firm initiated
Class II06/23/2022

Family Dollar Stores, Llc.

CGMP Deviations: product held outside appropriate storage temperature conditions.

OngoingVoluntary: Firm initiated
Class II02/10/2017

Synergy Rx

Lack of Assurance of Sterility: There are also CGMP Deviations.

TerminatedVoluntary: Firm initiated

Side Effects Reported to FDA

FDA FAERS database · These are reported events, not confirmed side effects

drug ineffective52,890 reports
dry skin45,322 reports
skin burning sensation41,860 reports
acne39,350 reports
erythema38,510 reports
skin irritation26,452 reports
skin exfoliation21,327 reports
inappropriate schedule of product administration16,204 reports
rash15,667 reports
overdose13,205 reports

Full Prescribing Information

Source: FDA Drug Label (SPL)For healthcare professionals

Indications & Usage

1 INDICATIONS AND USAGE Adapalene and benzoyl peroxide gel 0.1% / 2.5% is indicated for the topical treatment of acne vulgaris in patients 9 years of age and older. Adapalene and benzoyl peroxide gel 0.1% / 2.5% is a combination of adapalene, a retinoid, and benzoyl peroxide, and is indicated for the topical treatment of acne vulgaris in patients 9 years of age and older. (1)

Dosage & Administration

2 DOSAGE AND ADMINISTRATION For topical use only; adapalene and benzoyl peroxide gel 0.1% / 2.5% is not for oral, ophthalmic, or intravaginal use. Apply a thin film of adapalene and benzoyl peroxide gel 0.1% / 2.5% to affected areas of the face and/or trunk once daily after washing. Use a pea-sized amount for each area of the face (e.g., forehead, chin, each cheek). Avoid the eyes, lips and mucous membranes. Adapalene and benzoyl peroxide gel 0.1% / 2.5% is not for oral, ophthalmic, or intravaginal use. (2) Apply a thin film of adapalene and benzoyl peroxide gel 0.1% / 2.5% to affected areas of the face and/or trunk once daily after washing. Use a pea-sized amount for each area of the face (e.g., forehead, chin, each cheek). Avoid the eyes, lips and mucous membranes. (2)

Contraindications

4 CONTRAINDICATIONS None None. (4)

Drug Interactions

7 DRUG INTERACTIONS Concomitant topical acne therapy should be used with caution because a possible cumulative irritancy effect may occur, especially with the use of peeling, desquamating, or abrasive agents. No formal drug-drug interaction studies were conducted with adapalene and benzoyl peroxide gel 0.1% / 2.5%.

Adverse Reactions

6 ADVERSE REACTIONS Most commonly reported adverse events (≥1%) in patients treated with adapalene and benzoyl peroxide gel 0.1% / 2.5% were dry skin, contact dermatitis, application site burning, application site irritation and skin irritation. (6) To report SUSPECTED ADVERSE REACTIONS, contact Encube Ethicals Private Limited, at 1-833-285-4151 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. During clinical trials, 1401 subjects were exposed to adapalene and benzoyl peroxide gel 0.1% / 2.5%. A total of 1036 subjects with acne vulgaris, 12 years and older, were treated once daily for 12 weeks to 12 months. Related adverse events reported within 12 weeks of treatment and in at least 1% of subjects treated with adapalene and benzoyl peroxide gel 0.1% / 2.5% and those reported in subjects treated with the vehicle gel are presented in Table 1 : Table 1. Drug Related Adverse Events Reported in C

Frequently Asked Questions

What is Adapalene used for?

Adapalene is a retinoid gel applied to the skin to treat acne. It is available over-the-counter and works by helping to unclog pores and reduce acne breakouts.

Is Adapalene a controlled substance?

Adapalene is not classified as a controlled substance by the DEA.

What is the generic name for Adapalene?

The generic name for Adapalene is Adapalene. There are 4 other brand versions of Adapalene.

What is the NDC code for Adapalene 1 mg/g?

The NDC (National Drug Code) for Adapalene 1 mg/g is 0363-4110, listed by Walgreens.